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肖波

教授


xiaob@sustech.edu.cn

个人简介:

肖波,南方科技大学生物学系 教授,博士生导师,深圳市国家级科技领军领军人才。现任担任中国神经科学学会理亊、国家科技部项目评审专家、教育部学位与研究生教育发展中心评审专家, 教育部科技发展中心评审专家, 国家自然科学基金委评审专家,以及国家科技奖励评审专家。主要从事神经与精神疾病机理的细胞和分子生物学研究,采用遗传修饰小鼠制备人类疾病模型。作为首席科学家承担“973重大科学研究计划项目”。主持国家自然科学基金生命科学部重点项目(2016-2020)。在脑髓鞘发育、脑细胞能量代谢和抗氧化损伤研究领域处于世界领先水平。已相继在Developmental Cell, Nature Neuroscience, 及Neuron等国际著名杂志上发表论文20余篇,被引用>4,600次。连续五年(2014-2018)被Elsevier(爱思唯尔)评为中国神经科学领域高被引学者。

研究领域:

◆神经元-胶质细胞相互功能调节在健康与疾病中的作用

◆少突胶质细胞与髓鞘发育的分子调控;

◆小胶质细胞与神经退行性病变/再生;

◆神经细胞代谢和氧化应激与神经退行性病变。

工作经历:

1993年-1997年: 加拿大多伦多大学 博士后研究;

1997年-2000年: 美国约翰·霍普金斯大学神经科学系工作博士后;

2000-20005: 美国约翰·霍普金斯大学神经科学系Research Faculty;

2005-2018:四川大学教授; 华西医院神经发育与代谢研究室主任;

2017-至今: 南方科技大学终生教授。

学习经历:

1991/9 – 1993/7,北京医科大学,免疫学,博士

1986/9 – 1989/7,华西医科大学,免疫学,硕士

1979/9 – 1984/7,华西医科大学,临床医学,学士

所获荣誉:

2019: 深圳市国家级科技领军人才;

2008-2014: 国家科技部“973”项目首席科学家;

2008: 四川省优秀外籍教师

代表文章:

1.Yang W, Pang D, Du C, Jiang W, Luo L, Yu Z, Tang P, Xia X, Cui Y, Chen C, Liu Y, Wei Y-Q, Worley P.F, Xiao B*. Rheb1 controls mitochondrial energy metabolism by activating pyruvate dehydrogenase independently of mTORC1. Nature Communications,2019, submitted

2.Tan H, Chen M, Xia X, Pang D, Du C, Yang W, Cui Y, Huang C, Jiang W, Li C, Shang H, Worley PF, Xiao B*. LanCL1 Promotes Motor Neuron Survival and Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice. Cell Death and Differentiation, 2019, submitted

3.Li ZTseng PYTiwari VXu QHe SQWang YZheng QHan LWu ZBlobaum ALCui YTiwari VSun SCheng YHuang-Lionnet JHGeng YXiao BPeng JHopkins CRaja SNGuan YDong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017; 7;114(10):E1996-E2005.

4.Ahuja MSchwartz DMTandon MSon AZeng MSwaim WEckhaus MHoffman VCui YXiao BWorley PFMuallem SOrai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity. Cell Metabolism. 2017 Mar 7;25(3):635-646.

5.Eunchai Kang, Ju Young Kim, Cindy Y Liu, Bo Xiao, Po Yu Chen, Kimberly M Christian, Paul F Worley, Hongjun Song, Guo-li MingRheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus. Neurogenesis  2015; 2(1)

6.Zou Y, Jiang W, Zhang J, Bu J, Wang J, Zou J, Zhou L, Yu S, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B*.Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. Journal of Neuroscience. 2014, 34(47):15764-15778

7.Huang C, Chen M, Pang D, Bi D, Zou Y, Xia X, Yang W, Luo L, Deng R, Tan H, Zhou L,Yu S, Guo L, Du X, Cui Y, Hu J, Mao Q, Worley PF, Xiao B*. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Developmental Cell. 2014;30(4): 479-487 (Featured Article)

8.Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PU, Worley PF, Bo Xiao*. Rheb1 is Required for mTORC1 and Myelination in Postnatal Brain Development. Developmental Cell. 2011;20(1):97-108

9.Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience, 2013; 16(2):174-82

10.Cao Y, Tao L, Shen S, Xiao J, Wu H, Li B, Wu X, Luo W, Xiao Q, Hu X, Liu H, Nie J, Lu S, Yuan B, Han Z, Xiao B, Yang Z, Li X.Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice. Int J Mol Sci. 2013;14(12):24380-98.

11.Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell2013;154(3):637-50

12.Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N,  Liu S, Jaramillo TC, Bangash M, XiaoB, Worley PF, and Powell CM.  Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission. Journal of Neuroscience 2013, 33(47): 18448-18468

13.Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK.Homers at the Interface between Reward and Pain. Front Psychiatry. 2013; 7;4:39

14.Hu JHYang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I Metabotropic glutamate receptors. Nature Neuroscience, 2012;15(6),836-844

15.Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature Immunology.2011; 12(4):295-303

16.Smith-HicksC, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured cerebellar Purkinje cells. Nature Neuroscience. 2010;13(9): 1082-1089

17.Hu JH, Park JM, Park S, Xiao B, Dehoff MD, Kim S, Hayashi T, Schwarz M, Huganir RL, Seeburg PH, Linden DJ, Worley PF. Homeostatic Scaling requires Group I mGluR activation mediated by Homer1a 2010;68(6):1128-1142

18.Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. 2009;30(6):832-844

19.Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. 2001;411(6840):962-965

20.Xiao B, Tu JC, Worley PF. Homer: a link between neural activity and glutamate receptor function (invited). Curr Opin Neurobiol.2000;10(3):370-374

21.Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Lanahan AA, Wenthold RJ, Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron.1998;21(4):707-716

22.Tu JC, Xiao B(co-first author), Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Lanahan AA, Sheng M, Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron.1999;23(3):583-592

23.Tu JC, Xiao B(co-first author), Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21(4):717-726

24.Beneken J, Tu JC, Xiao B, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron.2000;26(1):143-154

WELCOME TO BIOLOGY DEPARTMENT


  • 地址:

    广东省深圳市南山区学苑大道1088号
              南方科技大学第一科研楼2-3层

  • biology@sustc.edu.cn
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