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张严冬

助理教授

第一科研楼335
zhangyd@sustc.edu.cn

个人简介

张严冬, 2007年博士毕业于美国华盛顿州立大学分子生物学院。2008年至2013年在美国华盛顿大学(圣路易斯)医学院分子肿瘤系从事博士后研究。主要致力于研究癌基因如何调节细胞生长繁殖的分子机制。

 

研究领域

 (1) RNA解旋酶的生物功能

  ( 2 )  癌症细胞生物学

  ( 3 )  免疫细胞修饰

 

工作经历

2013年—至今,     南方科技大学生物系,助理教授

2008年—2013年,  博士后研究, Molecular Oncology, School of Medicine, Washington University in St. Louis, MO

 

教育背景

2001-2007年, 理学博士 , 生物化学, Washington State University

1997-2000年, 理学硕士, 生物化学专业, 吉林大学

1993-1997年, 学士, 生物化学专业, 吉林大学生命科学院

 

获奖情况及荣誉

深圳市孔雀计划 (2014)

 

代表文章

1.Zhang, Y., Wang, Z., Magnuson, NS. (2007) Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and localization in H1299 cells. Mol. Can. Res. 5 (9): 909-922

2.Zhang, Y., Wang, Z., Li, X., Magnuson, NS. (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene,27:4809-4819

3.Zhang, Y., Forys, JT., Miceli, A., Gwinn, A., Weber, JD. (2011) Identification of DHX33 as a mediator in rRNA synthesis and cell growth. Molecular Cellular Biology (spotlight) 2011, 31 (23), 4676-4691

4.Zhang,Y., Saporita,A., Weber, JD. p19ARF and Ras V12 offer opposing regulation of DHX33 translation to dictate tumor cell fate. Molecular Cellular Biology 2013 Apr,33(8):1594-607

5.Zhang Y., Baysac KC, Yee LF, Saporita AJ, Weber JD. Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers. Breast Cancer Res. 2014 Sep 28;16(5):449

6.Zhang,Y#., You, J., Wang, XS., Weber, JD# The DHX33 RNA Helicase Promotes mRNA Translation Initiation Molecular Cellular Biology Sep 1, 2015;35(17):2918-31 #, corresponding author

7.Wu, C.*#, You, J*. , Fu, J*. , Wang, XS, Zhang, Y#. PI3K/Akt mediates integrin signaling to control RNA polymerase I transcription. Molecular Cellular Biology, 2016, 36 (10), #, corresponding author

8.Fu, JJ., Liu, YC., Wang,XS., Yuan, BL., Zhang, Y#. Role of DHX33 in c-Myc induced human cancers, Carcinogenesis, 2017 Jun 1;38(6):649-660, #, corresponding author

9.Yuan, BL., Wang, XS., Fan, CY., You, J., Liu, YC., Weber, JD., Zhong, HB#., Zhang, Y#. DHX33 transcriptionally controls genes involved in cell cycle. Molecular Cellular Biology. 36(23):2903-2917,2016 Sep, #, corresponding author

10.Wang, XS., Ge, W., Zhang, Y#. Recombinant DHX33 protein possesses dual DNA-RNA helicase activity, Biochemistry, 2018 June, #, corresponding author

11.Wang, HZ., Yu, JY., Wang, XS., Zhang, Y#. The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition. 2018, Cellular Signaling, 2018 Dec, #, corresponding author

12. Su, D., Yuan, BL., Su, CJ., Zhang, Y#. A 54-kDa short variant of DHX33 functions in regulating mRNA translation, Journal of Cellular Physiology, 2019 Jan, #, corresponding author

13. Wang, JL., Feng, WM., Yuan, Z., Weber, JD and Zhang, Y#. DHX33 interacts with AP-2 to regulate Bcl-2 gene expression and promote cancer cell survival. Molecular Cellular Biology, 2019 May, accepted, #, corresponding author

WELCOME TO BIOLOGY DEPARTMENT


  • 地址:

    广东省深圳市南山区学苑大道1088号
              南方科技大学第一科研楼2-3层

  • biology@sustc.edu.cn
  • 南科大生物系官方公众号

  • 南方科技大学官方公众号

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