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南方科技大学青年千人+珠江团队带头人翟继先课题组10万以上年薪招聘科研助理

日期 2017 06 06/分类 课题组岗位

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工作地点:深圳

薪金:年薪10万以上

学历和研究方向:生物信息、分子生物

招聘岗位:科研助理或访问学生

联系方式:zhaijx@sustc.edu.cn

 

翟继先介绍: http://www.sustc.edu.cn/biology_04/f/Zhai_jixian

感兴趣的同学请将个人简历和代表论文发送到  zhaijx@sustc.edu.cn

 

研究方向 (生物信息学和分子生物学相结合):

表观遗传组学,染色体高级结构,DNA甲基化,non-coding RNA

 

应聘条件:

1)在分子生物学或生物信息学相关专业领域已毕业或即将毕业的本科,硕士,或博士在读生;

2)撰写的研究论文已在高水平国际学术期刊发表或接收发表者优先考虑;

3)有NGS文库构建或测序数据分析经验优先考虑;

4)有植物相关研究经历优先考虑。

 

聘期待遇以发展前景:

基本工资7000-10000元/月,13薪,另外每年有17840元的福利费(餐补,高温补贴,过节费和计生奖等)。除此以外,学校承担五险一金和支付住房公积金。

 

个人简介:

翟继先05年本科毕业于中国科学技术大学,08年在中科院遗传与发育生物学研究所曹晓风院士指导下获得遗传学硕士,13年在Blake Meyers教授指导下获得美国特拉华大学博士学位(同期还完成了生物信息和统计学的两个硕士),之后加入加州大学洛杉矶分校美国科学院院士Steve Jacobsen课题组从事博士后研究。16年入选中组部“千人计划”青年项目并加入南方科技大学生物系。17年入选广东省珠江人才计划广创团队带头人(资助2000万),目前已经在主流期刊上发表了46篇文章,其中第一作者(或共一)8篇,包括Cell, PNAS, Genes&Development, The Plant Cell, PLoS Genetics等顶尖期刊。

 

代表文章:

At SUSTech

  1. Kuo HY, Jacobsen E, Long Y, Chen X, Zhai J# (2017) Characteristics and processing of Pol IV transcripts in Arabidopsis. Journal of Genetics and Genomics in press. (#corresponding author)
  2. Nan GL, Zhai J, Arikit S, Morrow D, Fernandes J, Mai L, Nguyen N, Meyers BC, Walbot V (2016), a master basic helix-loop-helix factor, regulates the specification and development of tapetum in maize Development dev.140673
  3. Ausin I, Feng S, Yu C, Liu W, Kuo HY, Jacobsen EL, Zhai J, Gallego-Bartolome J, Wang L, Egertsdotter U, Street NR, Jacobsen SE, Wang H (2016) DNA methylome of the 20-gigabase Norway spruce genome. PNAS 113(50):E8106-13

 

At previous institutions

First author research papers:

  1. Zhai J*, Bischof S*, Wang H, Feng S, Lee T, Teng C, Chen X, Park SY, Liu L, Gallego-Bartolome J, Liu W, Henderson I, Meyers BC, Ausin I, Jacobsen SE (2015) A ‘One precursor, One siRNA’ model for Pol IV-dependent siRNA Biogenesis. Cell 163, 445–455 (*co-first author)
  2. Zhai J*, Zhang H*, Arikit S, Huang K, Nan G, Walbot V, Meyers BC (2015) Spatiotemporal and cell-type dependent phasiRNA biogenesis in maize male reproduction. PNAS 112(10): 3146-51 (*co-first author)
  3. Zhai J, Zhao Y, Simon SA, Huang S, Petsch K, Arikit S, Pillay L, Ji L, et al. (2013) Plant microRNAs display differential 3’-truncation and tailing, modifications which are ARGONAUTE1-dependent and conserved across species. The Plant Cell 25(7):2417-28
  4. Zhai J, Jeong D-H, Paoli ED, Park S, Rosen BD, Li Y, González AJ, Yan Z, et al. (2011) MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. Genes & Development 25(23):2540-53.
  5. Zhai J, Liu J, Liu B, Li P, Meyers BC, Chen X, Cao X. (2008) Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genetics 4, e1000056.
  6. Song X*, Li P*, Zhai J*, Zhou M, Ma L, Liu B, Jeong DH, Cao S, Cui X et al. (2011) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. The Plant Journal 69, 462-474. (*co-first author)
  7. Zhai J, Arikit S, Simon SA, Kingham B, Meyers BC (2013) Construction of Parallel Analysis of RNA End (PARE) Library for Illumina Hi-Seq sequencing. Methods S1046-2023(13)00237-5
  8. Zhai J and Meyers BC (2013). Deep Sequencing from hen1 Mutants to Identify Small RNA 3′ Modifications. Cold Spring Harb Symp Quant Biol 1943-4456

Co-authored papers (in reverse-chronological order):

  1. Yu Y, Ji L, Le B, Zhai J, Chen J, Luscher E, Gao L, Liu C, Cao X, Mo B, Ma J, Meyers BC, Chen X (2017) ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology, in press.
  2. Groth M, Moissiard G, Wirtz M, Wang H, GarciaSalinas G, Ramos-Parra PA, Bischof S, Feng S, Cokus SJ, John A, Smith DC, Zhai J, Hale CJ, Long JA, Hell R, Garza RID, Jacobsen SE (2016) MTHFD1 controls DNA methylation in Arabidopsis. Nature Communication 2016 Jun 13;7:11640
  3. Wang H, Beyene G, Zhai J, Feng S, Fahlgren N, Taylor N, Bart R, Carrington JC, Jacobsen SE, Ausin I (2015) CG gene body DNA methylation changes and evolution of duplicated genes in cassava. PNAS 112(44):13729-34
  4. Yan Z, Hossain MS, Valdés-López O, Hoang NT, Zhai J, Wang J, Libault M, Joshi T, Brechenmacher L, Findley S, Qiu L, Sherrier DJ, Meyers BC, Xu D, Stacey G (2015) Identification and functional characterization of soybean root hair microRNAs expressed in response to Bradyrhizobium japonicum infection. Plant Biotechnology Journal 10.1111/pbi.12387
  5. Tu B, Xu C, Liu L, Zhai J, Li S, Lopez MA, Zhao Y, Yu Y, Ren G, Yu B, Li S, Meyers BC, Mo B, Chen X (2015) Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis. PLoS Genetics 11(4): e1005119
  6. Yan Z, Hossain MS, Arikit S, Valdé O, Zhai J, Wang J, Libault M, Ji T, Qiu L, Meyers BC, Stacey G (2015) Identification of MicroRNAs and their mRNA targets during soybean nodule development: Functional analysis of the role of miR393* in soybean nodulation. New Phytologist 10.1111/nph.13365
  7. Zhao M, Cai C, Zhai J, Lin F, Li L, Shreve J, Thimmapuram J, Hughes TJ, Meyers BC, Ma J (2015) Coordination of MicroRNAs, PhasiRNAs, and NB-LRR Genes in Immune Responses: Insights from Analyses of Soybean Rps Gene Near-Isogenic Lines. The Plant Genome 10.3835
  8. Cantó-Pastor A, Mollá-Morales A, Ernst E, Dahl W, Zhai J, Yan Y, Meyers BC, Shanklin J, Martienssen RA (2015) Efficient transformation and artificial miRNA gene silencing in Lemna minor. Plant Biology 10.1111/plb.12215
  9. Arikit S, Xia R, Kakrana A, Huang K, Zhai J, Yan Z, Valdés-López O, Prince S, Musket TA, Nguyen HT, Stacey G, Meyers BC (2014) An atlas of soybean small RNAs demonstrates regulation by phased siRNAs of hundreds of coding genes. The Plant Cell 26: 4584-4601
  10. Feng S, Cokus SJ, Schubert V, Zhai J, Pellegrini M, Jacobsen SE (2014) Genome-wide Hi-C analyses in wild type and mutants reveal high-resolution chromatin interactions in Arabidopsis. Molecular Cell 55(5):694-707
  11. Wong J, Gao L, Yang Y, Zhai J, Arikit S, Yu Y, Duan S, Xiong Q, Yan J, Li S, Liu R, Wang Y, Tang G, Meyers BC, Chen X, Ma W (2014) Roles of Small RNAs in Soybean Defense against Phytophthora sojae Infection. The Plant Journal 10.1111/tpj.12590
  12. Creasey KM, Zhai J, Borges F, Van EF, Meyers BC, Martienssen RA (2014) miRNAs trigger widespread epigenetically-activated siRNAs from transposons in Arabidopsis. Nature 508 (7496):411-5
  13. Wei L, Gu L, Song X, Cui X, Lua Z, Zhou M, Wang L, Hu F, Zhai J, Meyers BC, Cao X (2014) Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice. PNAS 111(10):3877-82
  14. Schapire A, Bologna NG, Moro B, Zhai J, Meyers BC, Palatnik JF (2013) Construction of Specific Parallel Amplification of RNA Ends (SPARE) libraries for the systematic identification of plant microRNA processing intermediates. Methods doi:10.1016/j.ymeth.2013.08.032
  15. Jeong DH, Schmidt SA, Rymarquis LA, Park S, Ganssmann M, German MA, Accerbi M, Zhai J, Paoli ED, Fahlgren N, Fox SE, Garvin DF, Mockler TC, Carrington JC, Meyers BC, and Green PJ (2013) Parallel Analysis of RNA Ends enhances global investigation of microRNAs and target RNAs of Brachypodium distachyon. Genome Biology 14(12):R145
  16. Amborella Genome Project. (2013) The Amborella Genome and the Evolution of Flowering Plants. Science 342(6165):1241089
  17. Jeong DH, Thatcher SR, Brown RS, Zhai J, Park S, Meyers BC, Green PJ (2013) Comprehensive investigation of miRNAs enhanced by analysis of sequence variants, expression patterns, AGO loading and target cleavage. Plant Physiology 162(3):1225
  18. Raman V, Simon SA, Romag A, Demirci F, Mathioni SM, Zhai J, Meyers BC, Donofrio NM (2013) Physiological stressors and invasive plant infections alter the small RNA transcriptome of the rice blast fungus Magnaporthe oryzae. BMC Genomics 14:326
  19. Bologna NG, Schapire AL, Zhai J, Chorostecki U, Boisbouvier J, Meyers BC, Palatnik J (2013) Multiple RNA recognition patterns during microRNA biogenesis in plants. Genome Research (10):1675-89
  20. Arikit S, Zhai J, Meyers BC (2013) Biogenesis and function of rice small RNAs from non-coding RNA precursors. Current Opinion in Plant Biology 16(2):170-9.
  21. Lee TF, Gurazada SG, Zhai J, Li S, Simon SA, Matzke MA, Chen X, Meyers BC (2012) RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. Epigenetics 7(7):781-95
  22. Zhao Y, Yu Y, Zhai J, Ramachandran V, Dinh T, Meyers BC, Mo B, Chen X (2012) HESO1, a nucleotidyl transferase in Arabidopsis, uridylates unmethylated miRNAs and siRNAs to trigger their degradation. Current Biology 22(8):689-94
  23. The_International_Medicago_Initiative (2011) The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature 480, 520-524
  24. Jeong D-H, Park S, Zhai J, Gurazada SGR, Paoli ED, Meyers BC, Green PJ. (2011) Massive analysis of rice small RNAs: Mechanistic implications of regulated miRNAs and variants for differential target RNA cleavage. The Plant Cell 23(12):4185-207.
  25. Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, Ding SW, Meyers BC, Vaucheret H, Chen X. (2010) siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Research 38(17):5844-5850.
  26. The International Brachypodium Initiative. (2010) Genome sequencing and analysis of the model grass Brachypodium distachyon. Nature 463(7282):763-768.
  27. Meyers BC, Simon SA, Zhai J. (2010) MicroRNA processing: battle of the bulge. Current Biology 20(2):R68-70. (review)
  28. Lee TF, Zhai J, Meyers BC. (2010) Conservation and divergence in eukaryotic DNA methylation. PNAS 107(20):9027-9028. (review)
  29. Simon SA, Zhai J, Nandety RS, McCormick KP, Zeng J, Mejia D, Meyers BC. (2009) Short-read sequencing technologies for transcriptional analyses. Annual Review Plant Biology 60:305-333. (review)
  30. Park W, Zhai J, Lee JY. (2009) Highly efficient gene silencing using perfect complementary artificial miRNA targeting AP1 or heteromeric artificial miRNA targeting AP1 and CAL genes. Plant Cell Rep 28(3):469-480.
  31. De Paoli E, Dorantes-Acosta A, Zhai J, Accerbi M, Jeong DH, Park S, Meyers BC, Jorgensen RA, Green PJ. (2009) Distinct extremely abundant siRNAs associated with cosuppression in petunia. RNA 15(11):1965-1970.
  32. Simon SA, Zhai J, Zeng J, Meyers BC. (2008) The cornucopia of small RNAs in plant genomes. Rice 1(1):52-62. (review)
  33. Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, Cao X. (2007) Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiology 144, 1913-1923.
  34. Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, et al. (2007) SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. The Plant Cell 19, 9-22.
  35. Xia R, Wang J, Liu C, Wang Y, Zhai J, Liu J, Hong X, Cao X, Zhu JK, Gong Z. (2006) ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. The Plant Cell 18, 85-103. 1(1):52-62.

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