研究副教授

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曹惠玲

研究副教授

0755-88018408
caohl@sustc.edu.cn

个人简介

        曹惠玲博士长期从事骨生物学领域的研究,研究内容主要涉及破骨细胞、成骨细胞的形成、分化的分子机制,骨重塑的分子机制,癌症骨转移及骨血管生成的相关分子机制,在以上领域有着丰富的研究经验。她主要以国际先进的模式动物为工具,阐明相关分子在骨骼发育及稳态维持中的作用,及其与骨骼相关疾病,如骨质疏松症、骨性关节炎、癌症骨转移等的关系,为临床治疗相关疾病提供最新的理论基础。曹惠玲博士多年担任多个SCI收入杂志的审稿人。她多次在国际、国内大会上做口头汇报,包括在骨研究领域国际上最权威的美国骨矿协会年会(ASBMR)上作报告,并多次获奖。

 

研究领域

1. 破骨细胞、成骨细胞的形成、分化的分子机制;
2. 骨重塑的分子机制;
3. 癌症骨转移;
4. 骨血管生成的分子机制。

 

工作经历

2010.07- 2011.08  美国匹兹堡大学      博士后
2014.11- 2016.12   南方科技大学生物系  工程师(讲师)
2017.01-               南方科技大学生物系  研究副教授

 

学习经历

2004.09-2010.07  中美联合培养博士(天津医科大学和美国匹兹堡大学)
1999.09-2004.07  天津医科大学  学士  医学检验专业

 

所获荣誉

1. Excellent PhD Graduate Award(2010年天津医科大学优秀博士毕业生)
Tianjin medical university, China, 2010
2. ASBMR Young Investigator Award, 2011(青年研究员奖)
ASBMR (American Society for Bone and Mineral Research) annual meeting, 2011, San Diego, California, USA
3. Young Investigator Award(青年研究员奖)
9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium, 2011, Nanjing, China
4. Chinese National Excellent Doctoral Dissertation nomination(2012年全国优秀博士学位论文提名论文)(Only 278 dissertations were nominated in 2012)
“Activating transcription factor 4 regulates osteoclast differentiation in mice”, Chinese Ministry of Education, 2012
5. Excellent Doctoral Dissertation Award (2012年天津市优秀博士学位论文)
Tianjin city, China, 2012
6. Shenzhen peacock scholar (Class C) (2015) (深圳孔雀学者)
7. ASBMR Young Investigator Travel Grant, 2016
Plenary Poster,ASBMR 2016 Annual Meeting, September 16-19, 2016, Atlanta, Georgia, USA

 

代表文章

1. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G*. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23; 4(10):e7583. PMCID: PMC2762317
2. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G*. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2; 120(8):2755-66. PMCID: PMC2912190
3. Yang S, Xu H, Yu S, Cao H, Fan J, Ge C, Fransceschi RT, Dong H, Xiao G*. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts, J Biol Chem, 2011. PMID: 21471200.
4. Xiao G, Cheng H, Cao H(co-first author), Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C. Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem, 2012. PMID: 22556421
5. Teramachi J, Hiruma Y, Ishizuka S, Ishizuka H, Brown JP, Michou L, Cao H, Galson DL, Subler MA, Zhou H, Dempster DW, Windle JJ, Roodman GD, Kurihara N. Role of ATF7-TAF12 interactions in the VDR hyper-sensitivity of osteoclast precursors in Paget’s disease. J Bone Miner Res. 2013. PMID:23426901
6. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G*. ATF4 regulates bone angiogenesis during development and in hypoxia in mice. J Bone Miner Res. 2013. PMID:23649506
7. Cao H, Zhu K, Qiu L, Li S, Niu H, Yang S, Zhao Z, Hao M, Anderson JL, Fan J, Roodman GD, Xiao G. Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis.  J Biol Chem, 2013. PMID:24005670
8. Qin T, Xu G, Qi J, Yang G, Zhang K, Liu H, Xu L, Xiang R, Xiao G, Cao H, Wei Y, Zhang Q, Li L. Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol. 2015. PMID: 26096340
9. Wu C, Jiao H, Lai, Y Zheng W, Chen K, Deng W, Song P, Zhu K, Cao H, Galson DL, Fan J, Im HJ, Liu Y, Chen J, Chen D, Xiao G. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015 Jul 7;6:7531. doi: 10.1038/ncomms8531. PMID: 26151572
10. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Aug 30. PMID: 27590440

 

联系方式

深圳市南山区西丽学苑大道1088号南方科技大学第一科研楼304室
邮编:518055
电子邮件:caohl@sustc.edu.cn

WELCOME TO BIOLOGY DEPARTMENT


  • 地址:

    广东省深圳市南山区学苑大道1088号
              南方科技大学第一科研楼2-3层

  • biology@sustc.edu.cn
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