研究副教授

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李思思

研究副教授

0755-88018446
liss6@sustc.edu.cn

个人简介

        李思思博士2013年从复旦大学毕业后,加入纽约纪念斯隆-凯特琳癌症中心从事博士后研究,师从美国国家科学院院士、美国艺术与科学院院士Dr. Dinshaw J. Patel教授。主要研究基因调控相关的结构生物学,多篇论文研究相继发表在PNAS、Nat Chem Biol.、Structure和Mol Cell等期刊上。

 

研究领域

基因调控相关的结构生物学

 

学习经历

2007.09-2013.01  复旦大学 博士
2001.09-2005.06  江苏大学 本科

 

所获荣誉

2012 国家一等奖学金
2012 罗氏诊断奖学金
2017 深圳市孔雀计划“C”类

 

代表文章

1. Li S#, Yen L#, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ and Jacobsen SE. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. PNAS. 2016, 113: E5108-16.(# co-first author)

2. Höfer K#, Li S#, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ and Jäschke A. Structure and function of the bacterial decapping enzyme NudC. Nat Chem Biol. 2016, 12: 730-4.(# co-first author)

3. Chen YC, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF and Aravin AA. Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Mol Cell. 2016, 63: 97-109.

4. Shi X, Ran Z, Li S, Yin J and Zhong J. The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo. Viruses. 2016, 8: 136.

5. Li S, Patel DJ. Drosha and Dicer: Slicers cut from the same cloth. Cell Res. 2016 26: 511-2.

6. Li S, Yang Z, Du X, Gozani O, Jacobsen SE, Patel DJ and Du J. Structural basis for the unique combinatorial readout of unmodified H3 tail by Arabidopsis ORC1b BAH-PHD cassette. Structure. 2016 24: 486-94.

7. Webster A, Li S, Hur JK, Wachsmuth M, Bois JS, Perkins EM, Patel DJ, Aravin AA. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol Cell. 2015 59: 564-75.

8. Kim B, Ha M, Loeff L, Chang H, Simanshu DK, Li S, Fareh M, Patel DJ, Joo C, Kim VN. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. EMBO J. 2015 34:1801-15.

9. Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, Chen YC, Luo Y, Sachidanandam R, Toth KF, Patel D, Aravin AA. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014 28:1667-80.

10. Du J, Johnson LM, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol Cell. 2014 55: 495-504.

11. Li B, Li S, Yin J, Zhong J. Identification and characterization of the Spodoptera Su(var)3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection. PLoS One. 2013 8: e69442

12. Li S, Du J, Yang H, Yin J, Ding J, Zhong J. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J.Mol.Cell Biol. 2013 5: 64-6.

 

联系方式

深圳市南山区西丽学苑大道1088号南方科技大学慧园4栋207
邮编:518055
电子邮件:liss6 (AT)sustc.edu.cn
电话:0755-88018446

 

WELCOME TO BIOLOGY DEPARTMENT


  • 地址:

    广东省深圳市南山区学苑大道1088号
              南方科技大学第一科研楼2-3层

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