院士/讲座教授

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Dinshaw.J.Patel

院士

慧园4栋205
dinshaw@sustc.edu.cn

个人简介

         Dinshaw J. Patel教授,1968年于美国纽约大学获得化学博士学位,同时在纽约大学医学院完成了一年的博士后研究,接着在美国电话电报公司(AT&T)贝尔实验室继续从事了两年的博士后工作。在美国电话电报公司获得了永久职位后开始了长达15年用核磁共振技术探索环肽,蛋白质和核酸结构的研究。1984年获得美国哥伦比亚大学终身教授职位,在之后的8年里一直从事用核磁共振技术探索核酸与靶向核酸药物的结构生物学研究。1992年被美国纪念斯隆-凯特琳癌症医院招募为教授,并着手建立结构生物学平台。从2000年开始转型用X射线衍射晶体学技术,结合其他生物化学和生物物理学手段来探寻生物体内有重要调控功能,与疾病密切相关的生物大分子的结构和功能。现为美国科学院院士,美国人文与科学院院士,美国纪念斯隆-凯特琳癌症医院教授,是RNA干扰和表观遗传学领域的国际知名结构生物学专家,发表过500余篇论文和综述,从其2003年至今的论文摘录里,每年都有大量的文章发表在Nature、 Science、 Cell等国际权威学术期刊上。于2015年11月引进为深圳市南方科技大学生物系讲座教授(兼职)。

 

研究方向

1.RNA沉默
2.表观遗传调控
3.胞内核酸受体
4.核酸开关及核酶
5.疾病相关的RNA蛋白复合物
6.转脂蛋白

 

工作经历
1967- 1968      美国纽约大学医学院                               生物化学博士后
1968-1969       美国电话电报公司贝尔实验室              生物物理博士后
1970-1984       美国电话电报公司贝尔实验室              工程师
1984-1992       美国哥伦比亚大学                                   教授
1992-至今       美国纪念斯隆-凯特琳癌症医院              教授
1994-至今       美国康奈尔大学医学院                            教授
2015-至今       中国科学院爱因斯坦讲席教授计划       讲席教授
2015-至今       深圳南方科技大学  生物系                     讲座教授(兼职)

 

学习经历
1957年—1961年      印度孟买大学           化学学士学位   
1961年—1963年     美国加州理工大学   化学硕士学位          
1963年—1968年     美国纽约大学           化学博士学位

 

所获荣誉
1961-1963      Jamshetjee N.Tata 学者
1983                美国电话电报公司贝尔实验室杰出工程师奖
1992                Abby Rockefeller Mauzé主任
1997                纽约大学杰出校友奖
1997-1999   (97-98)哈维机构副主席,(98-99)哈维机构主席
2013                美国国立卫生院院长革命创新性R01奖
2009               美国科学院院士
2014                美国人文与科学院院士

 

代表文章

2016

Saredi, G., Huang, H., Hammond, C., Bekker-Jensen, S., Forne, I., Reveron-Gomez, N., Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, N., Imhof, A., Patel, D. J. and Groth, A. (2016). H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature 534, 714-718.

Yang, H., Gao, P., Rajashankar, K. R., Patel, D. J. (2017). PAM-dependent target DNA recognition and cleavage by C2c1 CRISPR-Cas endonuclease. Cell 167,1814-1828.

Murn, J., Teplova, M., Zarnack, K., Shi, Y. and Patel, D. J. (2016). Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat. Struct. Mol. Biol. 23, 16-23.

Chen, Y-C. A., Stuwe, E., Luo, Y., Ninova, M., Thomas, A. L., Rozhavskaya, K., Li, S., Vempati, S., Laver, J. D., Patel, D. J., Smibert, C. A., Lipshitz, H. D., Toth, K. F. and Aravin, A. A. (2016). Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Mol. Cell 63, 97-109.

Prendergast, L., Muller, S., Liu, Y., Huang, H., Dingli, F., Lowe, D., Vassias, I., Patel, D. J., Sullivan, K. F. and Almouzni, G. (2016). The CENP-T- CENP-W complex is a binding partner of the histone chaperone FACT. Genes Dev. 30, 1313-1326.

Huang, H., Deng, Z., Vladimirova, O., Wiedmer, A., Lu, F., Lieberman, P. M. &amp; Patel, D. J. (2016). Structural basis underlying viral hijacking of a histone chaperone complex. Nat. Commun. 7: 12707.

Hofer, K., Li, S., Du, J., Abele, F., Frindert, J., Schlothauer, J., Grawenhoff, J., Patel, D. J., Jaschke, A. (2016). Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 12, 730-734.

Ren, A., Vusurovic, N., Gebetsberger, J., Gao, P., Juen M., Kreutz, C., Micura, R. Patel, D. J. (2016). Pistol ribozyme adopts an embedded pseudoknot fold facilitating site-specific in-line self-cleavage. Nat. Chem. Biol. 12, 702-708.

Gao, P., Yang, H., Rajanshankar, K. R., Huang, Z. &amp; Patel, D. J. (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target recognition. Cell Research 26, 901-913.

Li, S., Yen, L., Pastor, W.A., Johnston, J. B., Shew, C., Du, J., Wu, H., Liu, W., Ho, J., Stender, B., Clark, A. T., Burlingame, A., Whitelaw, E., Daxinger, L., Patel, D. J. and Jacobsen, S. E. (2016). Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Proc. Natl. Acad. Scis USA 113: E5108-E5116.

2015

Du, J., Johnson, L. M., Jacobsen, S. E. and Patel, D. J. (2015). DNA methylation pathways and their crosstalk with histone methylation. Nat. Rev. Mol. Cell Biol. 16, 519-532.

Noh, K. M., Wang, H., Kim, H. R., Wenderski, W., Fang, F., Li, C., Dewell, S., Ferris, A., Hughes, S. H., Zheng, D., Melnick, A, Patel, D. J., Li, H. and Allis, C. D. (2015). Engineering of a histone recognition domain in Dnmt3a alters the epigenetic landscape and phenotypic features of mouse ESCs. Mol. Cell 59, 89-103.

Webster, A., Li, S., Hur, J. K., Wachsmuth, M., Bois, J., Perkins, E. M., Patel, D. J. and Aravin, A. A. (2015). Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by Krimper. Mol. Cell 59, 564-575.

Chen, S., Ze, Y., Wilkinson, A., Deshpande, A. J., Sidoli, S., Krajewski, K., Strahl, B. D., Garcia, B. A., Armstrong, S. A., Patel, D. J. and Gozani, O. (2015). The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-methylation at H3K79. Mol. Cell 60, 319-327.

Huang, H., Stromme, C. B., Saredi, G., Hodl, M., Strandsby, A., Strandsby, A., Gonzalez-Aguilera, C., Chen, S., Groth, A. and Patel, D. J. (2015). A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. Nat. Struct. Mol. Biol. 22, 618-626.

Dai, Q., Ren, A., Westholm J. O., Patel, D. J. and Lai, E. (2015). Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev.29, 48-62.

Chen, S., Ruflange, A., Huang, H., Nourani, A. and Patel, D. J. (2015). Structural basis of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev.29, 1326-1340.

Murn, J., Zarnack, K., Yang, Y. J., Durak, O., Murphy, E. A., Cheloufi, S., Gonzalez, D. M., Teplova, M., Curk, T., Zuber, J., Patel D. J., Ule, J., Luscombe, N. M., Tsai, L. H., Walsh, C. A. and Shi, Y. (2015). Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes Dev. 29, 501-512.

Kim, B., Ha, M., Leoff, L., Chang, H., Simanshu, D. K., Li, S., Patel, D. J., Joo, C. and Kim, V. N. (2015). TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. EMBO J. 34, 1801-1815.

Ren, A., Wang, X. C., Kellenberger, C. A., Rajashankar, K. R., Jones, R., Hammond, M. C. and Patel, D. J. (2015). Structural basis for molecular discrimination by a 3’,3’-cGAMP riboswitch. Cell Reports 11, 1-12.

Ren, A., Xue, Y., Peselis, A., Serganov, A., Al-Hashimi, H. and Patel, D. J. (2015). Structuraland Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Reports 13, 1800-1813.

Vasilyev, N., Polonskaia, A., Darnell, J. C., Darnell, R. B., Patel, D. J. and Serganov, A. (2015). Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP. Proc. Natl. Acad. Scis. USA. 112, E5391-E5400.

Kosutic, M., Neuner, S., Ren, A., Flur, S., Wunderlich, C., Mayrhofer, E., Vusurovic, N., Seikowski, J., Westhof, E., Hobartner, C., Patel, D. J., Kreitz, C. and Micure, R. (2015). A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class. Angew. Chemie Int. Edn. 54, 15128-15133.

Malinina, L., Simanshu, D. K., Zhai, X., Samygina, V. R., Kamlekar, R., Kenoth, R., Ochoa-Lizarralde, B., Molotkovsky, J. G., Patel, D. J. and Brown, R. E. (2015). Sphingolipid transfer proteins defined by the GLTP-fold. Quart. Rev. Biophys. 48, 281-322.

2014

Johnson, L. M., Du, J., Hale, C. J., Bischof, S., Feng, S., Chodavarapu, R. K., Zhong, X., Marson, G., Pellergrini, M., Segal, D. J., Patel, D. J. and Jacobsen, S. E. (2014). SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature 507, 124-128.

Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Snijders, A. P., Wang, Y., Patel, D. J., Berenguer, J., Brouns, S. J. and van der Oost, J. (2014). DNA-guided DNA interference by prokaryotic Argonaute. Nature 507, 258-261.

Zhong, X., Du, J., Hale, C. J., Gallego-Bartolome, J., Feng, S., Vashisht, A. A., Chory, J., Wohlschlegel, J. A., Patel, D. J. and Jacobsen, S. E. (2014). Molecular mechanism of action of plant DRM de novo DNA methyltransferases. Cell 157, 1050-1060.

Lim, J., Ha, M., Chang, H., Kwon, S. C., Simanshu, D. K., Patel, D. J. and Kim, V. N. (2015). Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell 159, 1365-1376.

Stroud, H., Do, T., Du, J., Zhong, X., Feng, S., Johnson, L., Patel, D. J. and Jacobsen, S. E. (2014). Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat. Struct. Mol. Biol. 21, 64-72.

Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J. and van der Oost, J. (2014). The evolutionary journey of Argonaute proteins. Nat. Struct. Mol. Biol. 21, 743-753.

Tian, Y., Simanshu, D. K., Ma, J. B., Park, J-E, Heo, I., Kim, V. N. & Patel, D. J. (2014). A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol. Cell 53, 606-616.

Du, J., Johnson, L. M., Groth, M., Feng, S., Hale, C. J., Li, S., Vashisht, A. A., Gallego-Bartolome, J., Wohlschlegel, J. A., Patel, D. J. and Jacobsen, S. E. (2014). Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol. Cell 55, 495-504.

Lee, M., Choi, Y., Kim, K., Jin, H., Lim, J., Nguyen, T. A., Yang, J., Jeong, M., Giraldez, A. J., Yang, H., Patel, D. J. and Kim, V. N. (2015). Adenylation of maternally inherited microRNAs by Wispy. Mol Cell 56, 696-707.

Ren, A. and Patel, D. J. (2014). c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat. Chem. Biol. 10, 780-786.

Ren, A., Kosutic, M., Rajashankar, K. R., Frener, M., Santner, T., Westhof, E., Micura, R. and Patel, D. J. (2014). In-line alignment and Mg2+ coordination at the cleavage site of the twister ribozyme. Nat. Commun.15: 5534.

Cheng, Z., Cheung, P., Kuo, A. J., Yuki, E. T., Wilmot, C. M., Gozani, O. and Patel, D. J. (2014). A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev. 28, 1758-1771.

Le Thomas, A., Stuwe, E., LI, S., Du, J.,,Marinov, G., Rozhkov, N., Chen, A. Y-C., Luo, Y., Sachidanandam, R., Tot, K. F., Patel, D. J. and Aravin, A.A. (2014). Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 28, 1667-1680.

Simanshu, D., Zhai, X., Munch, D., Hofius, D., Markham, J. E., Bielawski, J., Bielawski, A., Slotte, J. P., Malinina, L., Molotkovsky, J. G., Mundy, J. E., Patel, D. J. and Brown, R. E. (2014). Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels. Cell Reports 6, 388-399.

Gao, P., Zillinger, T., Wang, W., Ascano, M., Dai, P., Hartmann, G., Tuschl, T., Deng, L., Barchet, W. and Patel, D. J. (2014). Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA. Cell Reports 8, 1668-1676.

 

WELCOME TO BIOLOGY DEPARTMENT


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