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谢宇聪

副教授

第一科研楼234
tseyc@sustc.edu.cn

个人简介

谢宇聪于2001年在香港中文大学取得生物技术学士学位,2002至2007年在香港中文大学姜里文教授指导下取得硕士及博士学位,并获得研究生科研成果奖。其后加入美国芝加哥大学Michael Glotzer课题组从事博士后研究,并于2013年加入南方科技大学生物系。目前已经在主流期刊上发表了20余篇文章,其中第一作者8篇,通讯作者2篇。

研究领域

目前,课题组主要研究两大领域:

(1) 研究细胞与发育生物学相关课题:主要利用人体细胞及秀丽隐杆线虫研究调控细胞分裂、细胞极性及细胞粘附的分子机理及相关器官发育机制。

(2) 开发荧光纳米探针应用于癌症治疗及检测:通过与化学领域的课题组合作,设计并合成荧光纳米探针,然后利用人体细胞及小鼠模型进行各类治疗及检测癌细胞的应用性研究。

研究经费

2017 深圳市科创委(基础研究)

2016 国家自然科学基金(面上项目)

2015 深圳市科创委(基础研究)

2014 国家自然科学基金(青年)项目

工作经历

2013 至今  南方科技大学,生物系,副教授;

2012       香港科技大学,博士后;

2007至2012 美國芝加哥大学分子遗存及细胞生物学系,博士后。

学习经历

2007,香港中文大学生物学博士学位;

2003,香港中文大学生物技术硕士学位;

2001,香港中文大学生物技术学士学位。

所获荣誉

深圳市海外高层次人才“孔雀计划”C类

代表文章

1. Li L, Wang S, Lan H, Gong G, Zhu Y, Tse YC#, Wong KM#. Rhodol Derivatives as Selective Fluorescent Probes for the Detection of HgII Ions and the Bioimaging of Hypochlorous Acid. ChemistryOpen 7: 136-143.
2. Li L, Wang C, Wu J, Tse YC#, Cai YP, Wong KM#. (2016) A Molecular Chameleon with Fluorescein and Rhodamine Spectroscopic Behaviors. Inorganic Chemistry 55: 205-213.
3. Basant A, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M. (2015) Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. Developmental Cell 33: 204-215
4. Tse YC*, Werner ME, Longhini MK, Labbe JC, Goldstein B, Glotzer M. (2012) RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4. Molecular Biology of the Cell 23: 4023-4031.
5. Tse YC*, Wang J, Jiang L. (2012) Multivesicular bodies in developing tobacco seed and mung bean are functionally equivalent. Plant Signaling & Behavior 7:1-4.
6. Tse YC*, Piekny A, Glotzer M. (2011) Anillin promotes astral microtubule-directed cortical myosin polarization. Molecular Biology of the Cell 22:3165-3175.
7. Wang J, Tse YC, Hinz G, Robinson DG, Jiang L. (2011) Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean. Journal of Experimental Botany 63:1367-1380.
8. Afshar K, Werner ME^, Tse YC^, Glotzer M, Gönczy P. (2010) Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Development 137:237-47. (^ these authors contributed equally to this work.)
9. Wang H, Tse YC, Law AH, Sun SS, Sun YB, Xu ZF, Hillmer S, Robinson DG, Jiang L. (2010) Vacuolar sorting receptors (VSRs) and secretory carrier membrane proteins (SCAMPs) are essential for pollen tube growth. The Plant Journal 61:826-838.
10. Tse YC*, Lam SK, Jiang L. (2009) Organelle identification and characterization in plant cells: Using a combinational approach of confocal immunofluorescence and electron microscope. Journal of Plant Biology 52:1-9.
11. Lam SK, Cai Y, Tse YC, Wang J, Law AH, Pimpl P, Chan HY, Xia J, Jiang L. (2009) BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. The Plant Journal 60:865-881.
12. Lam SK, Tse YC, Miao Y, Li HY, Wang J, Lo SW, Jiang L. (2007) Molecular characterization of plant prevacuolar and endosomal compartments. Journal of Integrative Plant Biology 49:1119-1128.
13. Lam SK, Tse YC, Robinson DG and Jiang L. (2007) Tracking down the elusive early endosome. Trends in Plant Science 12: 497-505.
14. Tse YC*, Lam SK and Jiang L. (2007) Enigmatic Brefeldin A. Plant Signaling & Behavior. Plant Physiology 2: 199-202.
15. Tse YC*, Lo SW, Hillmer S, Dupree P and Jiang L. (2006) Dynamic response of prevacuolar compartments to Brefeldin A in plant cells. Plant Physiology 142:1442-1459.
16. Oliviusson P, Heinzerling L, Hillmer S, Hinz G, Tse YC, Jiang L and Robinson DG. (2006) Plant retromer: identification, localization to the prevacuolar compartment and microvesicles, and preliminary evidence for an interaction with vacuolar sorting receptors. Plant Cell 18:1239-1252.
17. Tse YC*, Mo BX* and Jiang L. (2006) Plant prevacuolar/endosomal compartments. International Review of Cytology 253:95-129. (* these authors contributed equally to this work.)
18. Fung KL, Yim YF, Tse YC, Miao Y, Sun SSM and Jiang L. (2005) Targeting and processing of membrane-anchored YFP fusion proteins to protein storage vacuole in transgenic tobacco seeds. Seed Science Research 15:361-364.
19. Lam SK, Tse YC, Jiang L, Oliviusson P, Heinzerling L and Robinson DG. (2005) Plant prevacuolar compartments and endocytosis. In “Plant Endocytosis” Samaj, J., Baluska, F. and Menzel, D. (eds) Plant Cell Monographs 1:37-61.
20. Tse YC*, Mo B, Zhao M, Robinson DG, Hillmer S, Lo SW and Jiang L. (2004) Identification of multivescular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells. Plant Cell 16:672-693.
21. Jin JB, Bae H, Kim SJ, Jin YH, Goh CH, Kim DH, Lee YJ, Tse YC, Jiang L and Hwang I. (2003) The Arabidopsis dynamin-like proteins ADL1C and ADU1E play a critical role in mitochondrial morphogenesis. Plant Cell 15:2357-2369.
22. Mo B, Tse YC and Jiang L. (2003) Organelle identification and proteomics in plant cells. Trends in Biotechnology 21:331-332.
23. Li YB, Rogers SW, Tse YC, Lo SW, Sun SSM., Jauh GY and Jiang L. (2002) BP-80 and homologs are concentrated on post-Golgi, probable lytic prevacuolar compartments. Plant & Cell Physiology 43:726-742.
24. Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM. (2002) Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Science. 71:2267-2277.

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