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张严冬

助理教授

第一科研楼335
zhangyd@sustc.edu.cn

个人简介

        张严冬, 2007年博士毕业于美国华盛顿州立大学分子生物学院。2008年至2013年在美国华盛顿大学(圣路易斯)医学院分子肿瘤系从事博士后研究。主要致力于研究癌基因如何调节细胞生长繁殖的分子机制。工作主要发表在Molecular Cellular Biology, Oncogene, Molecular Cancer Research,Breast Cancer Research 等杂志

 

工作经历

◆ 2013.8-现在,南方科技大学生物系助理教授

◆2008.8-2013.5, 博士后研究, Molecular Oncology, School of Medicine, Washington University in St. Louis, MO

 

学习经历

◆2001-2007年, 理学博士 , 生物化学, Washington State University

◆1997-2000年, 理学硕士, 生物化学专业, 吉林大学

◆1993-1997年, 学士, 生物化学专业, 吉林大学生命科学院

 

所获荣誉

深圳市孔雀计划 (2014)

 

代表文章

1.Li-Qiang Zhang, Yan-Dong Zhang, Li Xu, Xiang-Lu Li, Xue-cheng Yang, Guang- Li Xu Xiao-Xia Wu, Hong-Yin Gao, Wei-Bin Du, Xue-Tao Zhang,  Xue-Zhong Zhang*, Lipase-Catalyzed Synthesis of RGD diamide in Aqueous Water-Miscible Organic Solvents. Enzyme Microb.Technol., 29: 129-135, 2001.

2.Zhang, Y., Wang, Z., Magnuson, NS. (2007)  Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and localization in H1299 cells. Mol. Can. Res.  5 (9): 909-922

3.Zhang, Y., Wang, Z., Li, X., Magnuson, NS. (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene   27:4809-4819

4.Wang, Z., Zhang, Y., Gu, JJ., Davitt, C., Reeves, R., Magnuson, NS. (2010) Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.  Int J Biochem Cell Biol. 42(6):1030-8

5.Zhang, Y., Forys, JT., Miceli, A., Gwinn, A., Weber, JD. (2011) Identification of DHX33 as a mediator in rRNA synthesis and cell growth. Molecular Cellular Biology (spotlight) 2011,  31 (23), 4676-4691,

6.Zhang,Y.,  Saporita,A., Weber, JD.  p19ARF and Ras V12 offer opposing regulation of DHX33 translation to dictate tumor cell fate.  Molecular Cellular Biology 2013 Apr; 33(8):1594-607.

7.Zhang,Y., Baysac, KC.,  Yee, LY., Saporita AJ., and Weber, JD Elevated DDX21 Regulates c-Jun Activity and rRNA Processing in Human Breast Cancers.  Breast Cancer Research  2014, Sep. 28;16(5):449

8.Zhang,Y*., You, J., Wang, XS., Weber, JD* DHX33 protein interacts with cytosolic translation initiation factors and ribosomes to promote mRNA translation. Molecular Cellular Biology Sep 1, 2015;35(17):2918-31 *, corresponding author

9.Wu, C.*, You, J. , Fu, J. , Wang, XS, Zhang, Y*. PI3K/Akt mediates integrin signaling to control RNA polymerase I transcription. Molecular Cellular Biology, 2016, 36 (10), *, corresponding author

10.Yuan, BL., Wang, XS., Fan, CY., You, J., Liu, YC., Weber, JD., Zhong, HB*., Zhang, Y*.   DHX33 transcriptionally controls genes involved in cell cycle. Molecular Cellular Biology 2016 Sep 6. pii: MCB.00314-16. [Epub ahead of print]  *, corresponding author

11. You, J., Wang, XS., Wang, JL., Yuan, BL., Zhang, Y*. DDX59 promotes DNA replication in lung adenocarcinoma, Cell Death and Discovery, 2017 (3),16095

12. Fu, JJ., Liu, YC., Wang,XS., Yuan, BL., Zhang, Y*. Role of DHX33 in c-Myc induced human cancers, 2017, Carcinogenesis, accepted

WELCOME TO BIOLOGY DEPARTMENT


  • 地址:

    广东省深圳市南山区学苑大道1088号
              南方科技大学第一科研楼2-3层

  • biology@sustc.edu.cn
  • 南科大生物系官方公众号

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